Managing Injection-Site Reactions (ISRs)

A number of nursing interventions help to limit the occurrence of injection-site reactions. Here are some suggestions for improving subcutaneous injections:

• Use the proper injection technique as instructed by a nurse or physician
• Apply ice to area before and after injection
• Gently massage area after injection for at least two minutes; this helps disperse medicine and reduce irritation
• Inject only into healthy tissue
• Wait at least seven days before injecting in the same spot 
• Check the site for redness, tenderness, or swelling two hours after injection.
• Rotate injection sites and select subcutaneous sites that are preferred or are most comfortable
• Avoid over-exposure to sunlight or ultraviolet rays
• Use an analgesic as required (although you should check the most appropriate analgesic regimen with a doctor or nurse)
• Where possible and when available, some people may wish to consider using an autoinjector to increase convenience, comfort and compliance

Click here to view a summary of the available injection devices for MS therapies.

At no time should the information presented replace or supersede the recommendations of your own physician.  If you have any concerns, please take the information or questions to your physician.